The Science Behind the Technology

Science of Liposomal Delivery Technology

Science and testing are critical when creating liposomes.

Every ingredient requires a unique technique for its creation and scale-up to full manufacturing. There are several different tests that are performed to verify the size, shape, dispersal, and stability of the liposomes. These tests are done with special, very expensive equipment in a specialized material science lab – not all companies do this.

Specnova guarantees its LipoVantage™ ingredients with a robust set of testing methods to accurately validate the liposome’s stability at manufacturing as well as testing them throughout accelerated stability studies.

To validate a liposome, it must be characterized completely using the most sophisticated techniques including Zeta Potential, Dynamic Light Scattering Analysis (DLS), Scanning Electron Microscopy (SEM), and Cryo Transmission Electron Microscope (TEM).

Zeta potential values are studied and measured to confirm a strong encapsulation of the active ingredient and stable colloidal suspension. This results in protection against the degradation of the active component in the gastrointestinal tract and thereby results in a more bioavailable, active component.

Dynamic Light Scattering Analysis (DLS) is conducted to identify the average size in nanometers of the liposome as well as to indicate the stability of the liposome due to increased surface-to-volume ratio. LipoVantage™ liposomes are around 175.3 nm in size. The decrease in particle size allows for an increase in bioavailability and results in a more stable colloidal suspension.

LipoVantage™ ingredients are shown to be stable using Cryo Transmission Electron Microscope (TEM) images. The image shows that the liposomes are spherical in shape, well dispersed, and there is minimal liposomal debris which might indicate vesical rupture. The core of the liposomal is well defined by the dark portion of the structure.

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